Genetic association of telomere length, obesity and tobacoo smoking with idiopathic pulmonary fibrosis risk.

ABSTRACT:

Background

Due to the inadequacy of published evidence, association of telomere length (TL), obesity and tobacco smoking with idiopathic pulmonary fibrosis (IPF) remains unclear. The aim of the study was to explore whether these exposures genetically affected the risk of the disease.

Methods

Genetic variants from genome-wide association studies for TL, body mass index (BMI), body fat percentage (BFP) and tobacco smoking (including maternal smoking) were used as instrumental variables. Inverse-variance weighted were mainly adopted to determine the genetic association of these exposures with IPF. All analyses were conducted by R-software (version 3.6.1).

Results

Firstly, longer TL was associated with the decreased risk of IPF (OR = 0.475 per SD increase in TL, 95%CI = 0

SUBMITTER: Wu W 

PROVIDER: S-EPMC10176771 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature