Accuracy of minimal residual disease detection by circulating tumor DNA profiling in lung cancer: a meta-analysis.

ABSTRACT:

Background

The sensitivity and specificity of minimal residual disease detected by circulating tumor DNA profiling (ctDNA MRD) in lung cancer, with particular attention to the distinction between landmark strategy and surveillance strategy, for predicting relapse in lung cancer patients after definitive therapy has yet to be determined.

Methods

The prognostic value of ctDNA MRD by landmark strategy and surveillance strategy was evaluated in a large cohort of patients with lung cancer who received definitive therapy using a systemic literature review and meta-analysis. Recurrence status stratified by ctDNA MRD result (positive or negative) was extracted as the clinical endpoint. We calculated the area under the summary receiver operating characteristic curves, and pooled sens

SUBMITTER: Zhong R 

PROVIDER: S-EPMC10176776 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature