Functional neuropathology of neonatal hypoxia-ischemia by single-mouse longitudinal electroencephalography.

ABSTRACT:

Objective

Neonatal cerebral hypoxia-ischemia (HI) results in symptomatic seizures and long-term neurodevelopmental disability. The Rice-Vannucci model of rodent neonatal HI has been used extensively to examine and translate the functional consequences of acute and chronic HI-induced encephalopathy. Yet, longitudinal electrophysiological characterization of this brain injury model has been limited by the size of the neonatal mouse's head and postnatal maternal dependency. We overcome this challenge by employing a novel method of longitudinal single-mouse electroencephalography (EEG) using chronically implanted subcranial electrodes in the term-equivalent mouse pup. We characterize the neurophysiological disturbances occurring during awake and sleep states in the acute and chronic ph

SUBMITTER: Johnson KJ 

PROVIDER: S-EPMC10176800 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature