Salivary proteins offer insights into keratinocyte death during aphthous stomatitis. A case-crossover study.

ABSTRACT:

Background

The death of oral keratinocytes is a crucial step in the emergence of recurrent aphthous stomatitis (RAS, also known as aphthae or aphthous ulcers). Since there are no experimental models available to research aphthous ulcers, little is understood about this process. We hypothesize that saliva can be a data bank of information that offers insights on epithelial damage.

Methods

In this case-crossover study, we assessed the salivary proteome of patients with RAS (n = 36) in the presence and absence of ulcers using discovery proteomics and bioinformatics. Additionally, we contrasted these patterns with those of healthy individuals (n = 31) who had no prior aphthous ulceration.

Results

Salivary proteome showed that during the ulcerative phase, controlled cell d

SUBMITTER: Cofre-Leiva C 

PROVIDER: S-EPMC10176878 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature