Detection of SARS-CoV-2 Antibodies in Immunoglobulin Products.

ABSTRACT:

Background

For patients with primary antibody deficiency, the first line of therapy is replacement with immunoglobulin (Ig) products. Prior to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, Ig products did not contain antibodies with specificity for this virus, and there have been limited data on the antibodies present in the Ig products in current use.

Objective

To quantitatively examine SARS-CoV-2 antibodies in current Ig products.

Methods

We examined 142 unique lots of 11 different Ig products intended for intravenous and/or subcutaneous delivery for IgG-binding activities against recombinant SARS-CoV-2 receptor binding domain, spike, and nucleocapsid proteins by enzyme-linked immunosorbent assays. In addition, to assess functionality, 4

SUBMITTER: Cousins K 

PROVIDER: S-EPMC10176888 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature