Exploring circular MET RNA as a potential biomarker in tumors exhibiting high MET activity.

ABSTRACT:

Background

MET-driven acquired resistance is emerging with unanticipated frequency in patients relapsing upon molecular therapy treatments. However, the determination of MET amplification remains challenging using both standard and next-generation sequencing-based methodologies. Liquid biopsy is an effective, non-invasive approach to define cancer genomic profiles, track tumor evolution over time, monitor treatment response and detect molecular resistance in advance. Circular RNAs (circRNAs), a family of RNA molecules that originate from a process of back-splicing, are attracting growing interest as potential novel biomarkers for their stability in body fluids.

Methods

We identified a circRNA encoded by the MET gene (circMET) and exploited blood-derived cell-free RNA (cfRNA)

SUBMITTER: Bersani F 

PROVIDER: S-EPMC10176894 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature