Capturing sex-specific and hypofertility-linked effects of assisted reproductive technologies on the cord blood DNA methylome.

ABSTRACT:

Background

Children conceived through assisted reproduction are at an increased risk for growth and genomic imprinting disorders, often linked to DNA methylation defects. It has been suggested that assisted reproductive technology (ART) and underlying parental infertility can induce epigenetic instability, specifically interfering with DNA methylation reprogramming events during germ cell and preimplantation development. To date, human studies exploring the association between ART and DNA methylation defects have reported inconsistent or inconclusive results, likely due to population heterogeneity and the use of technologies with limited coverage of the epigenome. In our study, we explored the epigenetic risk of ART by comprehensively profiling the DNA methylome of 73 human cord bl

SUBMITTER: Rahimi S 

PROVIDER: S-EPMC10176895 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature