Atherogenesis in <i>Apoe</i>^-/- and <i>Ldlr</i>^-/- Mice with a Genetically Resistant Background.

ABSTRACT: Apoe-deficient (Apoe^-/-) and Ldlr-deficient (Ldlr^-/-) mice are two common animal models of hypercholesterolemia and atherosclerosis. The two models differ in lipid and glucose metabolism and other mechanisms involved in atherogenesis. Here we examined atherosclerotic lesion formation in the two models with an atherosclerosis-resistant C3H/HeJ (C3H) background. 3-month-old C3H-Ldlr^-/- and C3H-Apoe^-/- mice developed minimal atherosclerotic lesions in the aortic root when fed a chow diet. After 12 weeks on a Western diet, C3H-Ldlr^-/- mice developed 3-fold larger lesions than C3H-Apoe^-/- mice in the aortic root (127,386 ± 13,439 vs. 41,542 ± 5075 μm²/section;

SUBMITTER: Torikai H 

PROVIDER: S-EPMC10177018 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature