Will Absolute Risk Estimation for Time to Next Screen Work for an Asian Mammography Screening Population?

ABSTRACT: Personalized breast cancer risk profiling has the potential to promote shared decision-making and improve compliance with routine screening. We assessed the Gail model's performance in predicting the short-term (2- and 5-year) and the long-term (10- and 15-year) absolute risks in 28,234 asymptomatic Asian women. Absolute risks were calculated using different relative risk estimates and Breast cancer incidence and mortality rates (White, Asian-American, or the Singapore Asian population). Using linear models, we tested the association of absolute risk and age at breast cancer occurrence. Model discrimination was moderate (AUC range: 0.580-0.628). Calibration was better for longer-term prediction horizons (E/O_{long-term ranges}: 0.86-1.71; E/O_{short-term ranges}:1.24-3.36).

SUBMITTER: Ho PJ 

PROVIDER: S-EPMC10177032 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature