The Membrane Protein Sortilin Is a Potential Biomarker and Target for Glioblastoma.

ABSTRACT: Glioblastoma (GBM) is a devastating brain cancer with no effective treatment, and there is an urgent need for developing innovative biomarkers as well as therapeutic targets for better management of the disease. The membrane protein sortilin has recently been shown to participate in tumor cell invasiveness in several cancers, but its involvement and clinical relevance in GBM is unclear. In the present study, we explored the expression of sortilin and its potential as a clinical biomarker and therapeutic target for GBM. Sortilin expression was investigated by immunohistochemistry and digital quantification in a series of 71 clinical cases of invasive GBM vs. 20 non-invasive gliomas. Sortilin was overexpressed in GBM and, importantly, higher expression levels were associated with worse patie

SUBMITTER: Marsland M 

PROVIDER: S-EPMC10177035 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature