Galectin-3 Is Associated with Cardiac Fibrosis and an Increased Risk of Sudden Death.

ABSTRACT:

Background

Myocardial fibrosis is a common postmortem finding among individuals with Sudden Cardiac Death (SCD). Numerous in vivo and in vitro studies have shown that increased galectin-3 (gal3) expression into the myocardium is associated with higher incidence of fibrosis. Although elevated gal3 expression is linked with myocardial fibrosis, its role in predicting the risk of SCD is unknown.

Methods

We reviewed the clinical datasets and post-mortem examination of 221 subjects who had died suddenly. We examined myocardial pathology including the extent of cardiac hypertrophy, fibrosis, and the degree of coronary atherosclerosis in these subjects. In a select group of SCD subjects, we studied myocardial gal3 and periostin expression using immunohistochemistry. To further exam

SUBMITTER: Sherpa MD 

PROVIDER: S-EPMC10177039 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature