The Challenges of Treating Patients with Breast Cancer and Obesity.

ABSTRACT: Obesity is defined as a body mass index (BMI) of 30 kg/m² or more and is associated with worse outcomes in patients with breast cancer, resulting in an increased incidence of breast cancer, recurrence, and death. The incidence of obesity is increasing, with almost half of all individuals in the United States classified as obese. Patients with obesity present with unique pharmacokinetics and physiology and are at increased risk of developing diabetes mellitus and cardiovascular disease, which leads to specific challenges when treating these patients. The aim of this review is to summarize the impact of obesity on the efficacy and toxicity of systemic therapies used for breast cancer patients, describe the molecular mechanisms through which obesity can affect systemic therapies, o

SUBMITTER: LeVee A 

PROVIDER: S-EPMC10177120 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature