Development and Application of a Physiologically Based Pharmacokinetic Model for Diclazuril in Broiler Chickens.

ABSTRACT: Withdrawal periods for diclazuril in broilers have traditionally been determined through regression analysis. However, over the last two decades, the physiologically based pharmacokinetic (PBPK) model has gained prominence as a predictive tool for veterinary drug residues, which offers an alternative method for establishing appropriate withdrawal periods for veterinary drugs. In this current study, a flow-limited PBPK model was developed to predict diclazuril concentrations in broilers following long-duration administration via medicated feed and water. This model consists of nine compartments, including arterial and venous plasma, lung, muscle, skin + fat, kidney, liver, intestine contents, and the rest of the body compartment. Physiological parameters such as tissue weights (V_cxx

SUBMITTER: Yang F 

PROVIDER: S-EPMC10177140 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature