Expression of Hemangioblast Proteins in von Hippel-Lindau Disease Related Tumors.

ABSTRACT: Von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome that targets a highly selective subset of organs causing specific types of tumors. The biological basis for this principle of organ selectivity and tumor specificity is not well understood. VHL-associated hemangioblastomas share similar molecular and morphological features with embryonic blood and vascular precursor cells. Therefore, we suggest that VHL hemangioblastomas are derived from developmentally arrested hemangioblastic lineage keeping their potential of further differentiation. Due to these common features, it is of major interest to investigate whether VHL-associated tumors other than hemangioblastoma also share these pathways and molecular features. The expression of hemangioblast proteins has not yet been assessed i

SUBMITTER: Vergauwen E 

PROVIDER: S-EPMC10177177 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature