High Intrinsic Oncogenic Potential in the Myc-Box-Deficient Hydra Myc3 Protein.

ABSTRACT: The proto-oncogene myc has been intensively studied primarily in vertebrate cell culture systems. Myc transcription factors control fundamental cellular processes such as cell proliferation, cell cycle control and stem cell maintenance. Myc interacts with the Max protein and Myc/Max heterodimers regulate thousands of target genes. The genome of the freshwater polyp Hydra encodes four myc genes (myc1-4). Previous structural and biochemical characterization showed that the Hydra Myc1 and Myc2 proteins share high similarities with vertebrate c-Myc, and their expression patterns suggested a function in adult stem cell maintenance. In contrast, an additional Hydra Myc protein termed Myc3 is highly divergent, lacking the common N-terminal domain and all

SUBMITTER: Lechable M 

PROVIDER: S-EPMC10177328 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature