Clinical Significance of microRNAs in Hematologic Malignancies and Hematopoietic Stem Cell Transplantation.

ABSTRACT: Hematologic malignancies are a group of neoplastic conditions that can develop from any stage of the hematopoiesis cascade. Small non-coding microRNAs (miRNAs) play a crucial role in the post-transcriptional regulation of gene expression. Mounting evidence highlights the role of miRNAs in malignant hematopoiesis via the regulation of oncogenes and tumor suppressors involved in proliferation, differentiation, and cell death. In this review, we provide current knowledge about dysregulated miRNA expression in the pathogenesis of hematological malignancies. We summarize data about the clinical utility of aberrant miRNA expression profiles in hematologic cancer patients and their associations with diagnosis, prognosis, and the monitoring of treatment response. Moreover, we will discuss the emer

SUBMITTER: Sevcikova A 

PROVIDER: S-EPMC10177548 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature