Radionuclide Therapy of HER2-Expressing Xenografts Using [¹⁷⁷Lu]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab.

ABSTRACT: ABY-027 is a scaffold-protein-based cancer-targeting agent. ABY-027 includes the second-generation Affibody molecule Z_HER2:2891, which binds to human epidermal growth factor receptor type 2 (HER2). An engineered albumin-binding domain is fused to Z_HER2:2891 to reduce renal uptake and increase bioavailability. The agent can be site-specifically labeled with a beta-emitting radionuclide ¹⁷⁷Lu using a DOTA chelator. The goals of this study were to test the hypotheses that a targeted radionuclide therapy using [¹⁷⁷Lu]Lu-ABY-027 could extend the survival of mice with HER2-expressing human xenografts and that co-treatment with [¹⁷⁷Lu]Lu-ABY-027 and the HER2-targeting antibody trastuzumab could enhance this effect. Balb/C nu/nu mice bearing H

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10177614 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature