Data driven clusters derived from resting state functional connectivity: Findings from the EMBARC study.

ABSTRACT:

Background

To address the clinical heterogeneity of Major Depressive Disorder (MDD), this investigation determined whether resting state functional magnetic resonance imaging (fMRI) could be deployed to identify circuit based homogeneous subgroups, and whether subgroups identified show differential treatment outcomes.

Methods

Pretreatment resting state fMRIs obtained from 278 outpatients with nonpsychotic MDD from Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care for Depression Study were used to create data-driven subgroups using CLICK clustering. These subgroups were then compared using baseline clinical data, as well as baseline-to-week 8 changes in depression severity measured using the 17-item Hamilton Rating Scale for Depression (HA

SUBMITTER: Chin Fatt CR 

PROVIDER: S-EPMC10177663 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature