Accelerated brain aging in individuals with diabetes: Association with poor glycemic control and increased all-cause mortality.

ABSTRACT:

Background

Diabetes has been linked to accelerated brain aging, i.e., neuroimaging-predicted age of brain is higher than chronological age. This report evaluated whether accelerated brain aging in diabetes is associated with higher levels of glycated hemoglobin (HbA1c) and increased mortality.

Methods

Brain age in Dallas Heart Study (n = 1949) was estimated using T1-weighted magnetic resonance imaging (MRI) scans and a previously-published Gaussian Processes Regression model. Accelerated brain aging (adjusted Δ brain age) was computed as follows: (brain age adjusted for chronological age)-minus-(chronological age). Mortality data until 12/31/2016 were obtained from the National Death Index. Associations of adjusted Δ brain age with diabetes in full sample and with HbA1c in i

SUBMITTER: Jha MK 

PROVIDER: S-EPMC10177664 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature