Effects of maternal social isolation on adult rodent offspring cognition.

ABSTRACT: Prenatal experiences can influence offspring physiology and behaviour through the lifespan. Various forms of prenatal stress impair adult learning and memory function and can lead to increased occurrence of anxiety and depression. Clinical work suggests that prenatal stress and maternal depression lead to similar outcomes in children and adolescents, however the long-term effects of maternal depression are less established, particularly in well controlled animal models. Social isolation is common in depressed individuals and during the recent COVID-19 pandemic. Accordingly, for this study we were interested in the effects of maternal stress induced via social isolation on adult offspring cognitive functions including spatial, stimulus-response, and emotional learning and memory that are me

SUBMITTER: McDonald RJ 

PROVIDER: S-EPMC10177704 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature