A Novel Two-Gene Expression-Based Prognostic Score in Malignant Pleural Mesothelioma.

ABSTRACT:

Background

Malignant pleural mesothelioma (MPM) is a rare cancer type with an increasing incidence worldwide. We aimed to develop a rational gene expression-based prognostic score in MPM using publicly available datasets.

Methods

We developed and validated a two-gene prognostic score (2-PS) using three independent publicly available gene expression datasets. The 2-PS was built using the Robust Likelihood-Based Survival Modeling with Microarray Data method.

Results

We narrowed down the model building to the analysis of 179 genes, which have been shown previously to be of importance to MPM development. Our statistical approach showed that a model including two genes (GOLT1B and MAD2L1) was the best predictor for overall survival (OS) (p < 0.0001). The binary scor

SUBMITTER: Shivarov V 

PROVIDER: S-EPMC10177801 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature