SerpinA3K Deficiency Reduces Oxidative Stress in Acute Kidney Injury.

ABSTRACT: We previously showed that SerpinA3K is present in urine from rats and humans with acute kidney injury (AKI) and chronic kidney disease (CKD). However, the specific role of SerpinA3K during renal pathophysiology is unknown. To begin to understand the role of SerpinA3K on AKI, SerpinA3K-deficient (KOSA3) mice were studied 24 h after inducing ischemia/reperfusion (I/R) and compared to wild type (WT) mice. Four groups were studied: WT+S, WT+IR, KOSA3+S, and KOSA3+IR. As expected, I/R increased serum creatinine and BUN, with a GFR reduction in both genotypes; however, renal dysfunction was ameliorated in the KOSA3+IR group. Interestingly, the increase in UH₂O₂ induced by I/R was not equally seen in the KOSA3+IR group, an effect that was associated with the preservation of

SUBMITTER: Gonzalez-Soria I 

PROVIDER: S-EPMC10177890 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature