Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD) is a prevalent type of dementia in elderly populations with a significant genetic component. The accumulating evidence suggests that AD involves a reconfiguration of the epigenetic landscape, including DNA methylation, post-translational modification of histone proteins, and chromatin remodeling. Along with environmental factors, individual specific genetic features play a considerable role in the formation of epigenetic architecture. In this study, we attempt to identify the non-coding regulatory SNPs (rSNPs) able to affect the epigenetic mechanisms in AD. To this end, the multi-omics approach is used. The GEO (Gene Expression Omnibus) available data (GSE153875) for AD patients and controls are integrated to reveal the rSNPs that display allele-specific features i

SUBMITTER: Bryzgalov LO 

PROVIDER: S-EPMC10177989 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature