Emergence of Nanoscale Drug Carriers through Supramolecular Self-Assembly of RNA with Calixarene.

ABSTRACT: Supramolecular self-assembly is a powerful tool for the development of polymolecular assemblies that can form the basis of useful nanomaterials. Given the increasing popularity of RNA therapy, the extension of this concept of self-assembly to RNA is limited. Herein, a simple method for the creation of nanosized particles through the supramolecular self-assembly of RNA with a three-dimensional macrocycle from the calixarene family was reported for the first time. This self-assembly into nanoparticles was realized using cooperative supramolecular interactions under mild conditions. The obtained nanoparticles are able to bind various hydrophobic (quercetin, oleic acid) and hydrophilic (doxorubicin) drugs, as a result of which their cytotoxic properties are enhanced. This work demonstrates tha

SUBMITTER: Kashapov R 

PROVIDER: S-EPMC10178118 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature