Pharmacological Evidence Suggests That Slo3 Channel Is the Principal K⁺ Channel in Boar Spermatozoa.

ABSTRACT: Sperm ion channels are associated with the quality and type of flagellar movement, and their differential regulation is crucial for sperm function during specific phases. The principal potassium ion channel is responsible for the majority of K⁺ ion flux, resulting in membrane hyperpolarization, and is essential for sperm capacitation-related signaling pathways. The molecular identity of the principal K⁺ channel varies greatly between different species, and there is a lack of information about boar K⁺ channels. We aimed to determine the channel identity of boar sperm contributing to the primary K⁺ current using pharmacological dissection. A series of Slo1 and Slo3 channel modulators were used for treatment. Sperm motility and related kinematic par

SUBMITTER: Cooray A 

PROVIDER: S-EPMC10178124 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature