Epithelial to mesenchymal transition in mammary gland tissue fibrosis and insights into drug therapeutics.

ABSTRACT:

Background

The epithelial-mesenchymal transition (EMT) is a multi-step morphogenetic process in which epithelial cells lose their epithelial properties and gain mesenchymal characteristics. The process of EMT has been shown to mediate mammary gland fibrosis. Understanding how mesenchymal cells emerge from an epithelial default state will aid in unravelling the mechanisms that control fibrosis and, ultimately, in identifying therapeutic targets to alleviate fibrosis.

Methods

The effects of EGF and high glucose (HG) on EMT in mammary epithelial cells, MCF10A and GMECs, as well as their pathogenic role, were studied. In-silico analysis was used to find interacting partners and protein-chemical/drug molecule interactions.

Results

On treatment with EGF and/or HG, qP

SUBMITTER: Syed MA 

PROVIDER: S-EPMC10178283 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature