Vitamin D Modulates the Response of Patient-Derived Metastatic Melanoma Cells to Anticancer Drugs.

ABSTRACT: Melanoma is considered a lethal and treatment-resistant skin cancer with a high risk of recurrence, making it a major clinical challenge. Our earlier studies documented that 1,25(OH)₂D₃ and its low-calcaemic analogues potentiate the effectiveness of dacarbazine and cediranib, a pan-VEGFR inhibitor. In the current study, a set of patient-derived melanoma cultures was established and characterised as a preclinical model of human melanoma. Thus, patient-derived cells were preconditioned with 1,25(OH)₂D₃ and treated with cediranib or vemurafenib, a BRAF inhibitor, depending on the BRAF mutation status of the patients enrolled in the study. 1,25(OH)₂D₃ preconditioning exacerbated the inhibition of patient-derived melanoma cell gr

SUBMITTER: Piotrowska A 

PROVIDER: S-EPMC10178305 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature