Intrauterine Smoke Exposure, microRNA Expression during Human Lung Development, and Childhood Asthma.

ABSTRACT: Intrauterine smoke (IUS) exposure during early childhood has been associated with a number of negative health consequences, including reduced lung function and asthma susceptibility. The biological mechanisms underlying these associations have not been established. MicroRNAs regulate the expression of numerous genes involved in lung development. Thus, investigation of the impact of IUS on miRNA expression during human lung development may elucidate the impact of IUS on post-natal respiratory outcomes. We sought to investigate the effect of IUS exposure on miRNA expression during early lung development. We hypothesized that miRNA-mRNA networks are dysregulated by IUS during human lung development and that these miRNAs may be associated with future risk of asthma and allergy. Human fetal lun

SUBMITTER: Rosenberg L 

PROVIDER: S-EPMC10178351 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature