The Functional Role and Regulatory Mechanism of FTO m⁶A RNA Demethylase in Human Uterine Leiomyosarcoma.

ABSTRACT: Uterine leiomyosarcoma (uLMS) is the most frequent subtype of uterine sarcoma that presents a poor prognosis and high rates of recurrence and metastasis. The origin and molecular mechanism underlying and driving its clinical and biological behavior remain largely unknown. Recently, we and others have revealed the role of microRNAs, DNA methylation, and histone modifications in contributing to the pathogenesis of uLMS. However, the connection between reversible m⁶A RNA methylation and uLMS pathogenesis remains unclear. In this study, we assessed the role and mechanism of FTO m⁶A RNA demethylase in the pathogenesis of uLMS. Immunohistochemistry analysis revealed that the levels of RNA demethylases FTO and ALKBH5 were aberrantly upregulated in uLMS tissues compared to ad

SUBMITTER: Yang Q 

PROVIDER: S-EPMC10178470 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature