Ultrastructural and Molecular Investigation on Peripheral Leukocytes in Alzheimer's Disease Patients.

ABSTRACT: Thriving literature underlines white blood cell involvement in the inflammatory processes of Alzheimer's Disease (AD). Among leukocytes, lymphocytes have been considered sentinels of neuroinflammation for years, but recent findings highlighted the pivotal role of neutrophils. Since neutrophils that infiltrate the brain through the brain vascular vessels may affect the immune function of microglia in the brain, a close investigation of the interaction between these cells is important in understanding neuroinflammatory phenomena and the immunological aftermaths that follow. This study aimed to observe how peripheral leukocyte features change at different stages of AD to identify potential molecular markers when the first features of pathological neurodegeneration arise. For this purpose, the

SUBMITTER: Giannelli R 

PROVIDER: S-EPMC10178539 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature