Molecular and Epigenetic Aspects of Opioid Receptors in Drug Addiction and Pain Management in Sport.

ABSTRACT: Opioids are substances derived from opium (natural opioids). In its raw state, opium is a gummy latex extracted from Papaver somniferum. The use of opioids and their negative health consequences among people who use drugs have been studied. Today, opioids are still the most commonly used and effective analgesic treatments for severe pain, but their use and abuse causes detrimental side effects for health, including addiction, thus impacting the user's quality of life and causing overdose. The mesocorticolimbic dopaminergic circuitry represents the brain circuit mediating both natural rewards and the rewarding aspects of nearly all drugs of abuse, including opioids. Hence, understanding how opioids affect the function of dopaminergic circuitry may be useful for better knowledge of th

SUBMITTER: Mazzeo F 

PROVIDER: S-EPMC10178540 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature