The Epithelial Sodium Channel-An Underestimated Drug Target.

ABSTRACT: Epithelial sodium channels (ENaC) are part of a complex network of interacting biochemical pathways and as such are involved in several disease states. Dependent on site and type of mutation, gain- or loss-of-function generated symptoms occur which span from asymptomatic to life-threatening disorders such as Liddle syndrome, cystic fibrosis or generalized pseudohypoaldosteronism type 1. Variants of ENaC which are implicated in disease assist further understanding of their molecular mechanisms in order to create models for specific pharmacological targeting. Identification and characterization of ENaC modifiers not only furthers our basic understanding of how these regulatory processes interact, but also enables discovery of new therapeutic targets for the disease conditions caused by ENaC

SUBMITTER: Lemmens-Gruber R 

PROVIDER: S-EPMC10178586 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature