Pro-Inflammatory Priming of the Brain: The Underlying Cause of Parkinson's Disease.

ABSTRACT: Parkinson's disease (PD) is a multifactorial neurodegenerative pathology characterized by the progressive loss of dopaminergic neurons in the substantia nigra of the brain. Aging is considered the main risk factor for the development of idiopathic PD. However, immunity and inflammation play a crucial role in the pathogenesis of this disorder. In mice, we showed that pro-inflammatory priming of the brain sensitizes to severe PD development, regardless of animal age. Age-related sub-acute inflammation, as well as the activation of the immune response upon exposure to harmful stimuli, enhances PD manifestations. The severity of PD is influenced by the engagement of host resistance mechanisms against infection based on the removal of iron (Fe) from the circulation. The sequestration of Fe by i

SUBMITTER: Martins AC 

PROVIDER: S-EPMC10178666 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature