Regulator of G-Protein Signalling 9: A New Candidate Gene for Sweet Food Liking?

ABSTRACT: Genetics plays an important role in individual differences in food liking, which influences food choices and health. Sweet food liking is a complex trait and has been associated with increased body mass index (BMI) and related comorbidities. This genome-wide association study (GWAS) aimed to investigate the genetics of sweet food liking using two adult discovery cohorts (n = 1109, n = 373) and an independent replication cohort (n = 1073). In addition, we tested the association of our strongest result on parameters related to behaviour (food adventurousness (FA) and reward dependence (RD) and health status (BMI and blood glucose). The results demonstrate a novel strong association between the Regulator of G-Protein Signalling 9 (RGS9I) gene, strongest single nucl

SUBMITTER: Graham CA 

PROVIDER: S-EPMC10178705 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature