Longitudinal association between overweight years, polygenic risk and NAFLD, significant fibrosis and cirrhosis.

ABSTRACT:

Background

Adiposity amplifies the genetic risk of non-alcoholic fatty liver disease (NAFLD).

Aim

We evaluated the association between overweight-years, a cumulative exposure based on the product of the duration and severity of excess body weight (body mass index (BMI) ≥ 25 kg/m² ), and genetic risk on liver fat and fibrosis.

Methods

This is a longitudinal analysis derived from a prospective cohort of adults in the Framingham Heart Study who underwent genotyping and vibration-controlled-transient-elastography with controlled attenuation parameter. Univariable and multivariable linear and logistic regression analyses were used to assess the association between overweight-years and liver fat and fibrosis. The association between genetic variants of liver fat

SUBMITTER: Ajmera V 

PROVIDER: S-EPMC10178778 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature