The Triad Na⁺ Activated Na⁺ Channel (Nax)-Salt Inducible KINASE (SIK) and (Na⁺ + K⁺)-ATPase: Targeting the Villains to Treat Salt Resistant and Sensitive Hypertension.

ABSTRACT: The Na⁺-activated Na⁺ channel (Nax) and salt-inducible kinase (SIK) are stimulated by increases in local Na⁺ concentration, affecting (Na⁺ + K⁺)-ATPase activity. To test the hypothesis that the triad Nax/SIK/(Na⁺ + K⁺)-ATPase contributes to kidney injury and salt-sensitive hypertension (HTN), uninephrectomized male Wistar rats (200 g; n = 20) were randomly divided into 4 groups based on a salt diet (normal salt diet; NSD-0.5% NaCl-or high-salt diet; HSD-4% NaCl) and subcutaneous administration of saline (0.9% NaCl) or deoxycorticosterone acetate (DOCA, 8 mg/kg), as follows: Control (CTRL), CTRL-Salt, DOCA, and DOCA-Salt, respectively. After 28 days, the following were measured: kidney function, blood pressu

SUBMITTER: Gonsalez SR 

PROVIDER: S-EPMC10178781 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature