Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Suppressive Capacity of Regulatory CD4 T Cells.

ABSTRACT: By virtue of mitochondrial control of energy production, reactive oxygen species (ROS) generation, and maintenance of Ca²⁺ homeostasis, mitochondria play an essential role in modulating T cell function. The mitochondrial Ca²⁺ uniporter (MCU) is the pore-forming unit in the main protein complex mediating mitochondrial Ca²⁺ uptake. Recently, MCU has been shown to modulate Ca²⁺ signals at subcellular organellar interfaces, thus fine-tuning NFAT translocation and T cell activation. The mechanisms underlying this modulation and whether MCU has additional T cell subpopulation-specific effects remain elusive. However, mice with germline or tissue-specific ablation of Mcu did not show impaired T cell responses in vitro or in vivo, indicating that

SUBMITTER: Jost P 

PROVIDER: S-EPMC10178810 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature