Ontology highlight
ABSTRACT:
SUBMITTER: Prockop SE
PROVIDER: S-EPMC10178844 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Prockop Susan E SE Hasan Aisha A Doubrovina Ekaterina E Dahi Parastoo B PB Rodriguez-Sanchez Irene I Curry Michael M Mauguen Audrey A Papanicolaou Genovefa A GA Su Yiqi Y Yao JinJuan J Arcila Maria M Boulad Farid F Castro-Malaspina Hugo H Cho Christina C Curran Kevin J KJ Giralt Sergio S Kernan Nancy A NA Koehne Guenther G Jakubowski Ann A Papadopoulos Esperanza E Perales Miguel-Angel MA Politikos Ioannis I Price Keith K Selvakumar Annamalai A Sauter Craig S CS Tamari Roni R Vizconde Teresa T Young James W JW O'Reilly Richard J RJ
The Journal of clinical investigation 20230515 10
BackgroundRefractory CMV viremia and disease are associated with significant morbidity and mortality in recipients of hematopoietic stem cell transplant (HCT).MethodsIn phase I/II trials, we treated 67 subjects for CMV viremia or disease arising after HCT with adoptive transfer of banked, third-party, CMVpp65-sensitized T cells (CMVpp65-VSTs). All were evaluable for toxicity and 59 for response. Evaluable subjects had CMV disease or persisting viremia that had failed at least 2 weeks of inductio ...[more]