Blood Metabolite Profiling of Antarctic Expedition Members: An ¹H NMR Spectroscopy-Based Study.

ABSTRACT: Serum samples from eight participants during the XV winter-over at Concordia base (Antarctic expedition) collected at defined time points, including predeparture, constituted the key substrates for a specific metabolomics study. To ascertain acute changes and chronic adaptation to hypoxia, the metabolic profiles of the serum samples were analyzed using NMR spectroscopy, with principal components analysis (PCA) followed by partial least squares and orthogonal partial least squares discriminant analyses (PLS-DA and OPLS-DA) used as supervised classification methods. Multivariate data analyses clearly highlighted an adaptation period characterized by an increase in the levels of circulating glutamine and lipids, mobilized to supply the body energy needs. At the same time, a reduction in the c

SUBMITTER: Del Coco L 

PROVIDER: S-EPMC10179003 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature