Pre-Diagnostic Saliva Microbiota of School-Aged Children Who Developed Type 1 Diabetes or Inflammatory Bowel Diseases.

ABSTRACT: Altered commensal microbiota composition has been associated with pediatric type 1 diabetes mellitus (T1D) and inflammatory bowel diseases (IBD), but the causal relationship is still unclear. To search for potential pre-diagnostic biomarkers for pediatric T1D or IBD, we compared microbiota in saliva samples in a nested case-control design comprising children developing T1D (n_children = 52) or IBD (n_children = 21) and controls with a similar age, sex, and residential area (n_children = 79). The pre-diagnostic saliva microbiota alpha- and beta-diversity of children who would develop T1D (n_samples = 27) or IBD (n_samples = 14) minimally varied from that of controls. The relative abundances of Abiotrophia were higher, while those of <

SUBMITTER: Raisanen L 

PROVIDER: S-EPMC10179007 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature