Towards Genetic Dissection of Skeletal Class III Malocclusion: A Review of Genetic Variations Underlying the Phenotype in Humans and Future Directions.

ABSTRACT:

Introduction

Skeletal abnormalities and malocclusions have varied features that impact populations globally, impairing aesthetics and lowering life quality. The prevalence of the Skeletal Class III disease is the lowest among all angle malocclusions, with varied prevalence across nations. Environmental, genetic, and societal factors play a role in its numerous etiologies. In this study, we conducted a thorough search across the published data relating to quantitative trait loci (QTL) and the genes associated with Class III progression in humans, discussed these findings and their limitations, and proposed future directions and strategies for studying this phenotype.

Methods

An inclusive search of published papers in the PubMed and Google Scholar search engines using the foll

SUBMITTER: Zohud O 

PROVIDER: S-EPMC10179046 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature