Absolute Stereochemistry and Cytotoxic Effects of Vismione E from Marine Sponge-Derived Fungus Aspergillus sp. 1901NT-1.2.2.

ABSTRACT: The metabolic profile of the Aspergillus sp. 1901NT-1.2.2 sponge-associated fungal strain was investigated using the HPLC MS technique, and more than 23 peaks in the HPLC MS chromatogram were detected. Only two minor peaks were identified as endocrocin and terpene derivative MS data from the GNPS database. The main compound was isolated and identified as known anthraquinone derivative vismione E. The absolute stereochemistry of vismione E was established for the first time using ECD and quantum chemical methods. Vismione E showed high cytotoxic activity against human breast cancer MCF-7 cells, with an IC₅₀ of 9.0 µM, in comparison with low toxicity for normal human breast MCF-10A cells, with an IC₅₀ of 65.3 µM. It was found that vismione E inhibits MCF-7 cell p

SUBMITTER: Girich EV 

PROVIDER: S-EPMC10179051 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature