Possible Association of Mutations in the MEFV Gene with the Intestinal Phenotype of Behcet's Disease and Refractoriness to Treatment.

ABSTRACT:

Background

Mediterranean fever (MEFV) gene mutations are responsible for familial Mediterranean fever (FMF) and associated with other inflammatory diseases. However, the effects of MEFV gene mutations on intestinal Behçet's disease (BD) are unknown. In this study, we investigated these mutations and clinical features in patients with intestinal BD.

Methods

MEFV gene analysis was performed in 16 patients with intestinal BD, 10 with BD without intestinal lesions, and 50 healthy controls. Clinical features of patients with intestinal BD were retrospectively assessed.

Results

The rates of MEFV gene mutations in patients with intestinal BD, BD without intestinal lesions, and healthy controls were 75%, 50%, and 38%, respectively. Only 2 of 12 pat

SUBMITTER: Furuta Y 

PROVIDER: S-EPMC10179346 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature