CysB Is a Key Regulator of the Antifungal Activity of Burkholderia pyrrocinia JK-SH007.

ABSTRACT: Burkholderia pyrrocinia JK-SH007 can effectively control poplar canker caused by pathogenic fungi. Its antifungal mechanism remains to be explored. Here, we characterized the functional role of CysB in B. pyrrocinia JK-SH007. This protein was shown to be responsible for the synthesis of cysteine and the siderophore ornibactin, as well as the antifungal activity of B. pyrrocinia JK-SH007. We found that deletion of the cysB gene reduced the antifungal activity and production of the siderophore ornibactin in B. pyrrocinia JK-SH007. However, supplementation with cysteine largely restored these two abilities in the mutant. Further global transcriptome analysis demonstrated that the amino acid metabolic pathway was significantly affected and that some sRNAs wer

SUBMITTER: Yu M 

PROVIDER: S-EPMC10179380 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature