Altered Functionality of Lipoprotein(a) Impacts on Angiogenesis in Diabetic Retinopathy.

ABSTRACT:

Purpose

Diabetic retinopathy (DR) is a complication of type 2 diabetes mellitus (T2DM). Lipoprotein(a) (Lp(a)) contributes to the progression of DR, but how is unclear. In homeostasis of the retinal microvasculature, myeloid-derived pro-angiogenic cells (PACs) also play a pivotal role, and fail to function properly in diabetic conditions. Here, we explored the putative contribution of Lp(a) from patients with T2DM with/without DR and healthy controls on inflammation and angiogenesis of retinal endothelial cells (RECs), and on PAC differentiation. Subsequently, we compared the lipid composition of Lp(a) from patients to that from healthy controls.

Methods

Lp(a)/LDL obtained from patients and healthy controls were added to TNF-alpha-activated RECs. Expression of VCAM-1/ICAM-1

SUBMITTER: Shariatzadeh M 

PROVIDER: S-EPMC10179636 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature