Effective Pre-Clinical Treatment of Fish Envenoming with Polyclonal Antiserum.

ABSTRACT: Envenomation by venomous fish, although not always fatal, is capable of causing damage to homeostasis by activating the inflammatory process, with the formation of edema, excruciating pain, necrosis that is difficult to heal, as well as hemodynamic and cardiorespiratory changes. Despite the wide variety of pharmacological treatments used to manage acute symptoms, none are effective in controlling envenomation. Knowing the essential role of neutralizing polyclonal antibodies in the treatment of envenoming for other species, such as snakes, this work aimed to produce a polyclonal antiserum in mice and test its ability to neutralize the main toxic effects induced by the venoms of the main venomous Brazilian fish. We found that the antiserum recognizes the main toxins present in the different

SUBMITTER: Lopes Ferreira M 

PROVIDER: S-EPMC10179662 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature