Novel Indoline Spiropyrans Based on Human Hormones β-Estradiol and Estrone: Synthesis, Structure, Chromogenic and Cytotoxic Properties.

ABSTRACT: The introduction of a switchable function into the structure of a bioactive compound can endow it with unique capabilities for regulating biological activity under the influence of various types of external stimuli, which makes such hybrid compounds promising objects for photopharmacology, targeted drug delivery and bio-imaging. This work is devoted to the synthesis and study of new spirocyclic derivatives of important human hormones-β-estradiol and estrone-possessing a wide range of biological activities. The obtained hybrid compounds represent an indoline spiropyrans family, a widely known class of organic photochromic compounds. The structure of the compounds was confirmed by ¹H and ¹³C NMR, IR, HRMS and single-crystal X-ray analysis. The intermolecular interaction

SUBMITTER: Ozhogin IV 

PROVIDER: S-EPMC10179760 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature