Graphene as Nanocarrier for Gold(I)-Monocarbene Complexes: Strength and Nature of Physisorption.

ABSTRACT: Gold(I) metal complexes are finding increasing applications as therapeutic agents against a variety of diseases. As their potential use as effective metallodrugs is continuously confirmed, the issue of their administration, distribution and delivery to desired biological targets emerges. Graphene and its derivatives possess attractive properties in terms of high affinity and low toxicity, suggesting that they can efficaciously be used as drug nanocarriers. In the present study, we computationally address the adsorption of a gold(I) N-heterocyclic monocarbene, namely, IMeAuCl (where IMe = 1,3-dimethylimidazol-2-ylidene), on graphene. The Au(I) N-heterocyclic carbene family has indeed shown promising anticancer activity and the N-heterocyclic ring could easily interact with planar graphene n

SUBMITTER: Orek C 

PROVIDER: S-EPMC10180098 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature