Cytotoxicity Evaluation of Photosensitizer-Conjugated Hexagonal Upconverting Nanoparticles.

ABSTRACT: In this report, we synthesized hexagonal NaYF₄:Yb,Er upconverting nanoparticles (UCNPs) of 171 nm in size with a narrow particle size distribution. To address their colloidal stabi-lity in aqueous media and to incorporate a photosensitizer that can produce reactive singlet oxygen (¹O₂) to kill tumor cells, UCNPs were conjugated with 6-bromohexanoic acid-functionalized Rose Bengal (RB) and coated with PEG-alendronate (PEG-Ale). The particles were thoroughly characterized by transmission electron microscopy, dynamic light scattering, ATR FTIR, X-ray photoelectron spectroscopy, thermogravimetric analysis, and spectrofluorometry, and ¹O₂ formation was detected using a 9,10-diphenylanthracene spectrophotometric probe. Cytotoxicity determina

SUBMITTER: Nahorniak M 

PROVIDER: S-EPMC10180129 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature