In Vivo Metabolite Profiling of DMU-212 in Apc^Min/+ Mice Using UHPLC-Q/Orbitrap/LTQ MS.

ABSTRACT: 3,4,5,4'-Trans-tetramethoxystilbene (Synonyms: DMU-212) is a resveratrol analogue with stronger antiproliferative activity and more bioavailability. However, the metabolite characterization of this component remains insufficient. An efficient strategy was proposed for the comprehensive in vivo metabolite profiling of DMU-212 after oral administration in Apc^Min/+ mice based on the effectiveness of the medicine. Ultra-high performance liquid chromatography-quadrupole/orbitrap/linear ion trap mass spectrometry (UHPLC-Q/Orbitrap/LTQ MS) in the AcquireX^TM intelligent data acquisition mode, combining the exact mass and structural information, was established for the profiling and identification of the metabolites of DMU-212 in vivo, and the possible metabolic pathways were

SUBMITTER: Li J 

PROVIDER: S-EPMC10180202 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature